科研探索
  • 标题: Age-associated reorganization of metabolic brain connectivity in Chinese children
    发表期刊: European Journal of Nuclear Medicine and Molecular Imaging 2019
    作者: Qi Huang1,2 & Jian Zhang3,4 & Tianhao Zhang2,5 & Hui Wang3 & Jianhua Yan6
    摘要:
    Purpose The human brain develops rapidly from infant to adolescent. Establishment of the brain developmental trajectory is important to understand cognition, behavior, and emotions, as well to evaluate the risk of neuropsychiatric disorders. 18F-FDG PET has been widely used to study brain glucose metabolism, but functional brain segregation and integration based on 18F-FDG PET remains largely unknown.
    Methods Two hundred one Chinese child patients with extracranial malignancy were retrospectively enrolled as surrogates to healthy children. All images were spatially normalized into MNI space using pediatric brain template, and the 18F-FDG uptakes were calculated for 90 regions using AAL atlas. The group-level metabolic brain network was constructed by measuring Pearsoncorrelation coefficients between each pair of brain regions in an inter-subject manner for infant (1 to 4 years), childhood (5 to 8 years), early adolescent (9 to 12 years), and adolescent (13 to 18 years) group, respectively. Global efficiency of each group was calculated, and the modular architectures were detected by a greedy algorithm.
    Results Both metabolic brain network connectivity and global efficiency increased with aging. Brain network was grouped into 4, 6, 4, and 4 modules from infant to adolescent, respectively. The modular architecture dramatically reorganized from childhood to early adolescent. The hubs spatiotemporally rewired. The ratio of the connector hub to the provincial hub increased from infant to early adolescent, but decreased during the adolescent period.
    Conclusions The topological properties and modular reorganization of human brain network dramatically changed with age, especially from childhood to early adolescence. These findings would help understand the Chinese developmental trajectory of human brain functional integration and segregation.
    关键词: Brain development . Metabolic brain network . Modularity . 18F-FDG PET
  • 标题: Prognostic value of metabolic indices and bone marrow uptake pattern on preoperative 18F–FDG PET/CT in pediatric patients with neuroblastoma
    发表期刊: Eur J Nucl Med Mol Imaging 2017
    作者: Chao Li1 & Jian Zhang1,2 & Suyun Chen1 & Shuo Huang1 & Shuqi Wu1 & Linlin Zhang1 & Fengxian Zhang1 & Hui Wang1
    摘要:
    Purpose To evaluate the prognostic value of metabolic parameters and bone marrow uptake (BMU) patterns on pretherapeutic 18-F-fluorodeoxyglucose (18F–FDG) positron emission tomography/computed tomography (PET/CT) in pediatric patients with neuroblastoma (NB). Patients and methods Forty-seven pediatric patients with newly diagnosed neuroblastoma who underwent 18F–FDG PET/CT were retrospectively reviewed. Clinicopathological factors and metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume(MTV), total lesion glycolysis (TLG) and bone marrow uptake patterns on PET/CTwere compared to predict recurrencefree survival (RFS) and overall survival (OS) by univariate and multivariate analysis.Results During the follow-up period, 27 (57.4%) patients experienced recurrence. MTV (P = 0.001),TLG (P = 0.004) and BMU patterns (P = 0.025) remained significant predictive factors for tumor recurrence, along with tumor size, histology, stage, lactate dehydrogenase (LDH) and other distant metastasis (except bone metastasis). Univariate analysis showed that histology, stage, tumor size (>37.25 cm), other distant metastasis, MTV (>88.10cm3) and TLG (>1045.2 g) and BMU patterns correlated with both RFS and OS (P < 0.05). On multivariate analysis, TLG remained the only independent prognostic factor for RFS (P = 0.016) andOS (P = 0.012), and BMU patterns and MTV were statistically significant for OS (P = 0.024 and P = 0.038, respectively). Conclusion Pretherapeutic 18F-FDG PET/CTcan provide reliable prognostic information for neuroblastoma pediatric patients, and patients with high MTV, TLG and focal bone marrow (unifocal and multifocal) uptake on PET/CT may have inferior outcomes during subsequent treatment.
    关键词: Neuroblastoma . Pet/ct . Metabolic tumor volume . Total lesion glycolysis . Bonemarrow involvement
  • 标题: Role of multi‑modality functional imaging in differentiation between benign and malignant thyroid 18F‑fluorodeoxyglucose incidentaloma
    发表期刊: Clinical and Translational Oncology 2019
    作者: H. Shi1,2 · Z. Yuan2 · C. Yang1,2 · J. Zhang1,2 · C. Liu1 · J. Sun1 · X. Ye3
    摘要:
    Purpose To evaluate the diagnostic performance of multi-modality functional imaging in differentiating malignant and benign thyroid 18F-fluorodeoxyglucose (18F-FDG) incidentaloma.
    Methods This study included 87 patients with thyroid 18F-FDG incidentalomas detected by 18F-FDG- positron emission tomography/computed tomography (18F-FDG-PET/CT) and diagnosed at surgery or biopsy, who received 18F-FDG-PET/CT, diffusion-weighted MR imaging (DWI) and ultrasound elastography (USE). The metabolic tumor volume (MTV), total lesion glycolysis (TLG), apparent diffusion coefficient (ADC) values and ultrasound elasticity scores of thyroid 18F-FDG incidentalomas were measured and compared in benign and malignant thyroid incidentalomas. The differences of malignant and benign thyroid incidentalomas were tested by χ2 test, Fisher’s exact test, t test, or Mann–Whitney U test. The diagnostic performance was evaluated and optimal cut-off values were determined in distinguishing malignant from benign thyroid incidentalomas by receiver operating characteristic curve analysis.
    Results MTV, TLG and USE scores of malignant thyroid incidentalomas were significantly higher than benign; but ADC value was significantly lower. We defined the functional imaging parameters TLG < 2.48, ADC > 1.80 × 10−3mm2/s, and USE score of 1 as markers of benign thyroid incidentalomas and each scored -1 point; TLG ≥ 2.48, ADC ≤ 1.80 × 10−3mm2/s, and USE score of 4 as markers of malignancy and each scored 1 point. Combined multi-functional imaging parameters achieved the highest performance (84.6% sensitivity and 97.1% specificity) for distinguish malignant from benign thyroid incidentaloma with AUC 0.957 (95% CI 0.917, 0.997).
    Conclusions Functional imaging might help to distinguishing malignant from benign thyroid 18F-FDG incidentalomas, and combined multi-functional imaging parameters could improve it.
    关键词: Neoplasms · thyroid · Positron emission tomography/computed tomography · Diffusion-weighted imaging · Ultrasound imaging · Elasticity imaging techniques