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标题： Construction of dual nanomedicines for the imaging and alleviation of atherosclerosis发表期刊： Artificial Cells, Nanomedicine, and Biotechnology 2020, VOL. 48, NO. 1, 169–179作者： Shuihua Zhang, Wan Xu, Peng Gao, Wenli Chen & Quan Zhou
摘要：Magnetic resonance imaging (MRI) is an essential tool for the diagnosis of atherosclerosis, a chronic cardiovascular disease. MRI primarily uses superparamagnetic iron oxide (SPIO) as a contrast agent. However, SPIO integrated with therapeutic drugs has rarely been studied. In this study, we explored biocompatible paramagnetic iron-oxide nanoparticles (NPs) in a complex with low pH-sensitive cyclodextrin for the diagnostic imaging and treatment of atherosclerosis. The NPs were conjugated with profilin-1 antibody (PFN1) to specifically target vascular smooth muscle cells (VSMCs) in the atherosclerotic plaque and integrated with the anti-inflammatory drug, rapamycin. The PFN1-CD-MNPs were easily binded to the VSMCs, indicating their good biocompatibility and low renal toxicity over the long term. Ex vivo near-infrared fluorescence (NIRF) imaging and in vivo MRI indicated the accumulation of PFN1-CD-MNPs in the atherosclerotic plaque. The RAP@PFN1-CD-MNPs alleviated the progression of arteriosclerosis. Thus, PFN1-CD-MNPs served not only as multifunctional imaging probes but also as nanovehicles for the treatment of atherosclerosis.
关键词： Molecular imaging; atherosclerosis; nanotherapy; profilin-1
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标题： 肝细胞癌合并胆管癌栓与肝内胆管细胞癌的CT、MRI鉴别诊断发表期刊： Modern Oncology 2020,28(01):0108-0113作者： 曾玉萍１，罗建东１，冷晓明１，刘庆余２，３摘要：
Objective:To investigate CT and MRI differential diagnosis between hepatocellular carcinoma with bile duct tumor thrombi(HCCBDTT)and cholangiocellular carcinoma(CCA).
Methods:The CT,MRI datas of 46 patients with HCCBDTT and 48 patients with CCA confirmed by pathology were analzyed retrospectively. The CT and MRI signs were statistically analyzed by two independent samples of t test and x2 test , and the difference between the two groups with P<0.05 had statistical significant.
Results: The CT and MRI signs such as, with or without capsule, he-patic lobe atrophy, intrahepatic bile duct dilatation, cirrhosis, portal vein tumor thrombus, portal vein slender, bile duct stones, retroperitoneal lymph nodes, CT enhancement mode and conventional enhancement T1 WI scan signal had sig-nificant statistical differences .
Conclusion : Some of the clinical symptoms and CT , MRI features between HCCBDTT and CCA may overlap , however , the comprehensive analysis combined with multiple statistical different signs has im-portant clinical value for the differential diagnosis of these two diseases.
关键词： hepatocellular carcinoma with bile duct tumor thrombi, cholangiocellular carcinoma, CT, MRI, differenti-al diagnosis
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标题： Imaging diagnosis of epithelioid hemangioendothelioma in thoracic vertebrae and liver发表期刊： 现代肿瘤医学 2020,28(01):108-113.作者： Yuping Zeng, MM, Xiaoming Leng, MD, Ping Chen, MB, Jiandong Luo, MD, Zhiyang Zhou, MD PhD
摘要：Epithelioid hemangioendothelioma (EHE) is a rare vascular tumor of uncertain biologic behavior. Most cases come out as a single lesion of the soft tissue but also may appear in the lung, liver, and other locations. EHE in bone, especially in thoracic vertebrae, is a extremely rare occurrence and signifies a challenge for the imaging diagnosis. This article presents a rare case of EHE occurring in thoracic vertebrae and liver revealed by fluoride-18-fluorodeoxyglucose-positron emission tomography and magnetic resonance imaging (18F-FDG-PET/MRI) to provide a better understanding of its clinical application and further insight into diagnosing a rare thoracic tumor.